My laboratory studies the molecular and genetic basis of sudden cardiac death in animal models, human families with inherited rhythm disorders, and populations at increased risk for sudden death. Pioneering studies in my laboratory engineered the first mouse models of long QT syndrome. Using these mouse models of arrhythmias and heart failure, we helped to define the ion channels important for cardiac repolarization, developed technologies for studying arrhythmias, and identified some of the basic mechanisms involved in the initiation and propagation of arrhythmias through collaborations with Dr. Guy Salama using optical mapping at the University of Pittsburgh.

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Lab Members